Casting an Eye Upon Alcor’s Board

If you're the type who likes to inspect the mechanisms behind the sausage, you should take a look at an article on Alcor's board over at Depressed Metabolism:

In January 2008, Alcor’s self perpetuating Board came under renewed scrutiny after long-time Alcor member and cryonics activist David Pizer tried to raise interest for changing the current system to a member elected Board.

Scrutiny of the board is a fine tradition for stakeholders in for-profit and non-profit initiatives, as is stakeholder activism to produce desired change. The concern voiced in the article is that born of the perceived need for change at Alcor - to better produce growth, increased professionalism, and so forth - and the concern that a self-perpetuating board has little incentive to make the changes that the writer would like to see happen.

Member-voted boards have their own issues, of course, not least that a member (as opposed to stakeholder) has no meaningful ownership right connected to their vote, but the pendulum swings as it chooses.

This is all, I think, I fairly good illustration of the transitionary period from volunteerism to professionalism one sees in any growing industry. The cryonics industry has been going through this phase for a long time, and remaining very small in size, for reasons that are much debated. Is it the fault of the business model, incredulous public perception, heavy regulation, a comparatively undiversified technology base, or the laundry list of other potential factors? Can be solved by changing the way people pay, by changes in regulatory structures, or by increased investment in research and building spin-off technology businesses? And so forth. These are all questions that have debated at length over the years.

What I think is most telling with regard to where the cryonics industry is at present is that you don't see a lot of discussion focused on change through competition. The traditional solution to undesirable characteristics within an industry is for entrepreneurs to set forth and compete, as "undesirable" usually means "customers will pay for something less undesirable." If you want change, then help to found a new company and do things the "right" way. Ongoing for-profit experiments in any number of different "right" ways are how progress is achieved and benefit brought to customers in the long term.

There needs to be more of that in the cryonics industry if the goal is directed change. The best way to make a board change their stripes is to look like you're going to eat their lunch out from under them; by doing that, you will also have gone a long way towards proving that your "right" way is in fact the right way for progress.

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The Murky Depths of Parkinson’s Disease

You might recall that the chemical alpha-synuclein is an aggregate that appears to be a proximate cause of Parkinson's disease (and like many biochemical aggregates, its buildup is slowed by the practice of calorie restriction). Researchers are delving deeper into the chain of mechanisms:

Patients with Parkinson's disease (PD) have elevated levels of the protein called alpha-synuclein in their brains. As the protein clumps, or aggregates, the resulting toxicity causes the death of neurons that produce the brain chemical dopamine. Consequently, nerves and muscles that control movement and coordination are destroyed.

The researchers discovered that the activity of three genes that control the synthesis of heme, the major component of hemoglobin that allows red blood cells to carry oxygen, precisely matched the activity of the alpha-synuclein gene, suggesting a common switch controlling both.

The scientists then found that a protein called GATA-1, which turns on the blood-related genes, was also a major switch for alpha-synuclein expression, and that it induced a significant increase in alpha-synuclein protein. Finally, they demonstrated that a related protein -- GATA-2 -- was expressed in PD-vulnerable brain cells and directly controlled alpha-synuclein production.

Researchers are taking a similar tack to that of mainstream Alzheimer's research now that a greater understanding of alpha-synuclein exists. Get rid of the aggregate, in other words:

"Simply lowering alpha-synuclein levels by 40 percent may be enough to treat some forms of Parkinson's disease," says Dr. Clemens Scherzer of Harvard. "So far, researchers have focused on ways to get rid of too much 'bad' alpha-synuclein in Parkinson patients' brains. Now we will be able to tackle the problem from the production site, and search for new therapies that lower alpha-synuclein production up front."

...

The studies showed that GATA-1 and GATA-2 proteins find the alpha-synuclein gene, stick to it and then directly control it.

"This is not an indirect pathway; it is direct regulation of the gene," says Bresnick. "This directness provides the simplest scenario for creating a therapeutic strategy."

The problem with influencing the production side is, of course, that everything in our biochemistry has many different roles. It's next to impossible to alter any gene or mechanism without causing unwanted side-effects. This is a strong incentive to focus primarily on cleaning up aggregates rather than re-engineering our metabolism, if those are the only two options on the table. Further options will hopefully emerge as researchers progress towards an understanding of why these mechanisms change with age. What form of known age-related biochemical damage is causing changes in GATA regulation - and thus alpha-synuclein levels - and how is it doing that?

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ekoh: A New Eco-Friendly In-Store/Online Boutique.

A great new eco-friendly online boutique just opened up in conjunction with The Cosmetic Market.

Ekoh_logo

Ekoh is an eco-conscious online boutique launched with a stellar array of prestige organic, natural and environmentally conscious beauty brands.

New and existing eco-friendly brands include: Jurlique , CARE by Stella McCartney, REN, Korres, Alison Raffaele, Kevin Murphy,  Shu Uemura, Malie, Tela, Sacred Locks, Body Sonya Dakar, Hamadi, Pangea, MOP, Herban Essentials, Ecoist Bags, Essence of Vali, Baggu Bags, Cargo PlantLove Lipstick, Dr. Hauschka and many more brands to come.

To start enjoying the new boutique, ekoh has offered us a fabulous discount so you can shop and receive 20% off everything that you order online. How great is that? All you have to do is use the code splendicity at checkout to get the 20% off!

Shop Now!!! Let me know if you scoop up anything!

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Anti-Aging Picks from Nordstrom’s Beauty Exclusives Event.

It is here! I have mentioned this annual even at Nordstrom’s, called Beauty Exclusives a few times now and I wanted to remind you of it again. The event started last Friday (July 18th) and sadly some of the goodies are sold out already. Alas, there are still some really terrific values during this event and I have made my picks.

philosophy ‘the microdelivery exfoliating wash’ - $48 (a $75 value)

image

PerriconeMD 30-Day Introductory Kit - $55 (an $86 value)
Clinique Dramatically Different Moisturizing Lotion - $36 (a $72 value)
Shiseido ‘White Lucent’ Set - $85 (a $128 value)
Kinerase® ‘Summer Essentials’ Anniversary Kit - $125 (a $275 value)
CAUDALIE Anniversary Kit 2008 - $27 (a $35 value)
Elemis Resurfacing System - $99 (a $252.50 value)
Sisley Cleansing Kit for Dry/Sensitive Skin  - $99.50 (a $120 value)

Now, if I can only narrow it down to one or two and figure out which products I really need. Let me know if you scoop anything up. Shop Nordstroms.com soon!

image credit: nordstrom.com

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How To Tell Whether It’s Working

How does one determine whether or not an advocacy website is actually working? A firm conviction that benefits are created is all well and good, but that won't get you very far in circles where resources are allocated on performance. The objectives of Fight Aging! are laid out in one of my annual signs of incredulity that I've been doing this for yet another year:

I have sought to bring those who stop by, or who otherwise stumble upon my writings, around to a more productive way of looking at aging, longevity, science and human action.

...

Sometimes our conversation is hard to find, however. People who might have learned and contributed do not do so; opportunities to broaden the healthy life extension community are lost. ... someone has to be talking on topic to keep the conversation growing, to avoid lapses in which newcomers might miss the party.

A nicely nebulous set of goals upon which to pin metrics. We can look at web statistics (one step beyond damned lies), participation in the healthy life extension community, funds raised for specific goals ... but it's a real challenge to determine what contribution my efforts made to a dynamic community or process of many contributers. Never mind how it could have all be accomplished more effectively or efficiently.

Those of you with longer memories will recall that sometimes people turn up out of the blue, lay down a seven-figure check, and say "yup, it was because of this advocacy initiative that I chose to donate." But it's rare - you can't base an analysis of success on huge checks from the blue. If you have enough of those to start counting, you've already won.

That particular seven-figure check justifies Fight Aging! for a good few more years yet, but vindication isn't really the purpose of metrics. Good advocates are one step removed from fanatics - they'll keep at it until the rest of the world gives in and admits the advocate was right all along. Metrics are about improvement: how can you do better with the resources to hand.

The online metric of first resort is web statistics, the damned lies mentioned above. I'm not all that sure that anything of worth can be derived from web statistics with respect to the goals of Fight Aging!. It's not even clear that more links, more traffic, or more aggregation are necessarily better - this is where those folk who are simply interested in monetizing websites have a much easier time of it. At the end of the day they can look at the dollars and rate of conversions to sale. Meanwhile I ponder the nature of my most popular page for this past year and wonder what most of my page views actually represent.

For Fight Aging!, a "conversion to sale" might be someone who sets off to become a molecular biologist or organize a fundraising conference for the Methuselah Foundation. I might be able to claim partial credit for one or two of those. At the less radical end of the scale, you'll find people who donate to fund SENS longevity research, or discuss healthy life extension with a friend where they might otherwise not have done. You get the idea - and I have no idea as to how well I'm doing there. Realistically, I'm never likely to know. Contributing to the new zeitgeist is not an activity for those who need personal validation, nor those who enjoy a nice, clean balance sheet of expenditure versus result.

So: I'm fairly convinced my work produces a continuing net positive influence, but proving that to anyone's satisfaction - beyond the generous million-dollar donor - is quite another story. In terms of improvement for the future, I'm left with the same old unsatisfactory metric of bulk visits and mailing list membership; I must assume that more is merrier until conclusively proven wrong on that front.

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